652 research outputs found

    The effect of the Coriolis force on Kelvin-Helmholtz-driven mixing in protoplanetary disks

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    We study the stability of proto-planetary disks with vertical velocity gradients in their equilibrium rotation rates; such gradients are expected to develop when dust settles into the midplane. Using a linear stability analysis of a simple three-layer model, we show that the onset of instability occurs at a larger value of the Richardson number, and therefore for a thicker layer, when the effects of Coriolis forces are included. This analysis also shows that even-symmetry (midplane-crossing) modes develop faster than odd-symmetry ones. These conclusions are corroborated by a large number of nonlinear numerical simulations with two different parameterized prescriptions for the initial (continuous) dust distributions. Based on these numerical experiments, the Richardson number required for marginal stability is more than an order of magnitude larger than the traditional 1/4 value. The dominant modes that grow have horizontal wavelengths of several initial dust scale heights, and in nonlinear stages mix solids fairly homogeneously over a comparable vertical range. We conclude that gravitational instability may be more difficult to achieve than previously thought, and that the vertical distribution of matter within the dust layer is likely globally, rather than locally, determined.Comment: Accepted for publication in Ap

    Metabolic determinants of body weight after cats were fed a low-carbohydrate high-protein diet or a high-carbohydrate low-protein diet ad libitum for 8wk

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    Overweight and obese conditions are common in cats and are associated with the development of a number of diseases. Knowledge of metabolic determinants and predictors of weight gain may enable better preventative strategies for obesity in cats. Lean, healthy cats were fed either a low-carbohydrate high-protein diet (n 16) or a high-carbohydrate low-protein (n 16) diet ad libitum for 8wk. Potential determinants and predictors of final body weight assessed were body fat and lean masses, energy required for maintenance, energy requirements above maintenance for each kilogram of weight gain, insulin sensitivity index, fasting, mean 24-h and peak plasma glucose, insulin, and leptin concentrations, and fasting and mean 24-h serum adiponectin concentrations. In cats fed the low-carbohydrate high-protein diet, after adjusting for initial body weight, those with higher energy requirements for weight gain and higher fasting glucose concentration had higher final body weights (P ≤ 0.01). Predicted final body weights using initial body weight, fasting glucose and mean 24-h insulin concentrations (partial R2 37.3%) were imprecise. An equation using just initial body weight and fasting glucose concentration would be of more practical value, but was marginally less precise. In cats fed the high-carbohydrate low-protein diet, those with lower fasting leptin concentration initially had higher final body weights (P = 0.01). Predicted final body weights using initial body weight, energy requirements for maintenance, total body fat percentage and fasting leptin concentration (partial R2 39.2%) were reasonably precise. Further studies are warranted to confirm these findings and to improve the precision of predicted final body weights

    Influência de estresse por déficit hídrico em acessos do gênero Paspalum.

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    Editado por Ana Rita de araĂşjo Nogueira, Simone Cristina MĂ©o Niciur

    Contribution of vascular endothelial growth factor to the Nottingham prognostic index in node-negative breast cancer

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    The prognostic contribution of intratumour VEGF, the most important factor in tumour-induced angiogenesis, to NPI was evaluated by using flexible modelling in a series of 226 N-primary breast cancer patients in which steroid receptors and cell proliferation were also accounted for. VEGF provided an additional prognostic contribution to NPI mainly within ER-poor tumours. © 2001 Cancer Research Campaignhttp://www.bjcancer.co

    Vascular endothelial growth factor in node-positive breast cancer patients treated with adjuvant tamoxifen

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    In 212 postmenopausal women with node-positive oestrogen receptor-positive (ER(LBA)) breast cancer subjected to radical surgery and adjuvant tamoxifen, the risk of 6-year relapse increased with increasing values of intratumoral vascular endothelial growth factor (VEGF) in patients whose tumours had a low/intermediate ER(LBA) content compared to patients with high-ER(LBA) tumours. These findings indicate that tumour progression, activated or sustained by high VEGF levels, may be counteracted in high-ER(LBA) cancers by tamoxifen, which in contrast fails to contrast the metastatic potential in low-ER(LBA) tumours
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